Arterial Chemoreceptors and Sympathetic Nerve Activity

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Arterial chemoreceptors and sympathetic nerve activity: implications for hypertension and heart failure.

Chronic elevation in sympathetic nerve activity (SNA) is associated with the development and maintenance of certain types of hypertension1 and contributes to the progression of chronic heart failure (CHF).2 The mechanisms involved in sympathetic dysfunction in these disorders appear to be complex and multifactorial. A unified hypothesis is likely to encompass alterations in multiple autonomic r...

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BACKGROUND Exogenous adenosine has been shown to increase muscle sympathetic nerve activity (MSNA), blood pressure, heart rate, and ventilation in conscious humans, effects attributed to peripheral chemoreceptor activation. METHODS AND RESULTS To determine whether endogenous adenosine has similar effects and whether they are mediated through chemoreceptor activation, we examined the effects o...

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Role of Arterial Chemoreceptors in Mediating the Effects of Endogenous Adenosine on Sympathetic Nerve Activit

Background Exogenous adenosine has been shown to increase muscle sympathetic nerve activity (MSNA), blood pressure, heart rate, and ventilation in conscious humans, effects attributed to peripheral chemoreceptor activation. Methods and Results To determine whether endogenous adenosine has similar effects and whether they are mediated through chemoreceptor activation, we examined the effects of ...

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Dynamic interactions between arterial pressure and sympathetic nerve activity: role of arterial baroreceptors.

The role of arterial baroreceptors in controlling arterial pressure (AP) variability through changes in sympathetic nerve activity was examined in conscious rats. AP and renal sympathetic nerve activity (RSNA) were measured continuously during 1-h periods in freely behaving rats that had been subjected to sinoaortic baroreceptor denervation (SAD) or a sham operation 2 wk before study (n = 10 in...

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Sympathetic Nerve Activity in Humans

In nine sedentary subjects (16.5±0.4 years, mean±SEM) we measured blood pressure (Finapres device), heart rate (electrocardiogram), and postganglionic muscle sympathetic nerve activity (micToneurography from the peroneal nerve) at rest and during intravenous infusion of phenylephrine and nitroprusside. These measurements were performed before and after 10 weeks of endurance training (2 h/d, 5 d...

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ژورنال

عنوان ژورنال: Hypertension

سال: 2007

ISSN: 0194-911X,1524-4563

DOI: 10.1161/hypertensionaha.106.076083